Heatmap

6 Clusters

pam_cluster Number of Genes
1 440
2 273
3 785
4 630
5 285
6 387
Total 2800

Expression Boxplots of Representative Genes

Expression Boxplots of Hrs, Gprk2, InR, Akt1 (Akt), and Pi3K92E

Enrichments

Cluster 1

## Uploading data to Enrichr... Done.
##   Querying GO_Biological_Process_2018... Done.
##   Querying GO_Molecular_Function_2018... Done.
##   Querying KEGG_2019... Done.
## Parsing results... Done.

GO Biological Processes

KEGG 2019

Cluster 2

## Uploading data to Enrichr... Done.
##   Querying GO_Biological_Process_2018... Done.
##   Querying GO_Molecular_Function_2018... Done.
##   Querying KEGG_2019... Done.
## Parsing results... Done.

GO Biological Processes

KEGG 2019

Cluster 3

## Uploading data to Enrichr... Done.
##   Querying GO_Biological_Process_2018... Done.
##   Querying GO_Molecular_Function_2018... Done.
##   Querying KEGG_2019... Done.
## Parsing results... Done.

GO Biological Processes

KEGG 2019

Cluster 4

## Uploading data to Enrichr... Done.
##   Querying GO_Biological_Process_2018... Done.
##   Querying GO_Molecular_Function_2018... Done.
##   Querying KEGG_2019... Done.
## Parsing results... Done.

GO Biological Processes

KEGG 2019

Cluster 5

## Uploading data to Enrichr... Done.
##   Querying GO_Biological_Process_2018... Done.
##   Querying GO_Molecular_Function_2018... Done.
##   Querying KEGG_2019... Done.
## Parsing results... Done.

GO Biological Processes

KEGG 2019

Cluster 6

## Uploading data to Enrichr... Done.
##   Querying GO_Biological_Process_2018... Done.
##   Querying GO_Molecular_Function_2018... Done.
##   Querying KEGG_2019... Done.
## Parsing results... Done.

GO Biological Processes

KEGG 2019

Enrichment Summary

KEGG

Gene Expression Plots

Cluster 1

Cluster 2

Session Info

## R version 4.0.5 (2021-03-31)
## Platform: x86_64-apple-darwin17.0 (64-bit)
## Running under: macOS Big Sur 10.16
## 
## Matrix products: default
## BLAS:   /Library/Frameworks/R.framework/Versions/4.0/Resources/lib/libRblas.dylib
## LAPACK: /Library/Frameworks/R.framework/Versions/4.0/Resources/lib/libRlapack.dylib
## 
## locale:
## [1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8
## 
## attached base packages:
##  [1] grid      parallel  stats4    stats     graphics  grDevices utils    
##  [8] datasets  methods   base     
## 
## other attached packages:
##  [1] cowplot_1.1.1                         seqLogo_1.56.0                       
##  [3] MotifDb_1.32.0                        enrichR_3.0                          
##  [5] ggpubr_0.4.0                          data.table_1.14.0                    
##  [7] DT_0.17                               msigdbr_7.2.1                        
##  [9] forcats_0.5.1                         dplyr_1.0.5                          
## [11] purrr_0.3.4                           readr_1.4.0                          
## [13] tidyr_1.1.3                           tibble_3.1.0                         
## [15] tidyverse_1.3.0                       factoextra_1.0.7                     
## [17] cluster_2.1.1                         stringr_1.4.0                        
## [19] enrichplot_1.13.0                     ReactomePA_1.34.0                    
## [21] clusterProfiler_3.18.1                BSgenome.Dmelanogaster.UCSC.dm6_1.4.1
## [23] BSgenome_1.58.0                       rtracklayer_1.50.0                   
## [25] pheatmap_1.0.12                       geneplotter_1.68.0                   
## [27] annotate_1.68.0                       XML_3.99-0.6                         
## [29] reshape_0.8.8                         lattice_0.20-41                      
## [31] gridExtra_2.3                         RColorBrewer_1.1-2                   
## [33] kableExtra_1.3.4                      Biostrings_2.58.0                    
## [35] XVector_0.30.0                        scales_1.1.1                         
## [37] reshape2_1.4.4                        knitr_1.31                           
## [39] biomaRt_2.46.3                        GenomicFeatures_1.42.3               
## [41] AnnotationDbi_1.52.0                  genefilter_1.72.1                    
## [43] ggplot2_3.3.3                         DESeq2_1.30.1                        
## [45] SummarizedExperiment_1.20.0           Biobase_2.50.0                       
## [47] MatrixGenerics_1.2.1                  matrixStats_0.58.0                   
## [49] GenomicRanges_1.42.0                  GenomeInfoDb_1.26.7                  
## [51] IRanges_2.24.1                        S4Vectors_0.28.1                     
## [53] BiocGenerics_0.36.0                  
## 
## loaded via a namespace (and not attached):
##   [1] utf8_1.2.1               tidyselect_1.1.0         htmlwidgets_1.5.3       
##   [4] RSQLite_2.2.6            BiocParallel_1.24.1      scatterpie_0.1.5        
##   [7] munsell_0.5.0            withr_2.4.1              colorspace_2.0-0        
##  [10] GOSemSim_2.16.1          highr_0.8                rstudioapi_0.13         
##  [13] ggsignif_0.6.1           DOSE_3.16.0              labeling_0.4.2          
##  [16] GenomeInfoDbData_1.2.4   polyclip_1.10-0          bit64_4.0.5             
##  [19] farver_2.1.0             rprojroot_2.0.2          downloader_0.4          
##  [22] vctrs_0.3.7              treeio_1.14.4            generics_0.1.0          
##  [25] xfun_0.22                BiocFileCache_1.14.0     R6_2.5.0                
##  [28] splitstackshape_1.4.8    graphlayouts_0.7.1       locfit_1.5-9.4          
##  [31] bitops_1.0-6             cachem_1.0.4             fgsea_1.16.0            
##  [34] DelayedArray_0.16.3      assertthat_0.2.1         ggraph_2.0.5            
##  [37] gtable_0.3.0             tidygraph_1.2.0          rlang_0.4.10            
##  [40] systemfonts_1.0.1        splines_4.0.5            rstatix_0.7.0           
##  [43] lazyeval_0.2.2           broom_0.7.6              checkmate_2.0.0         
##  [46] abind_1.4-5              BiocManager_1.30.12      yaml_2.2.1              
##  [49] modelr_0.1.8             crosstalk_1.1.1          backports_1.2.1         
##  [52] qvalue_2.22.0            tools_4.0.5              ellipsis_0.3.1          
##  [55] jquerylib_0.1.3          Rcpp_1.0.6               plyr_1.8.6              
##  [58] progress_1.2.2           zlibbioc_1.36.0          RCurl_1.98-1.3          
##  [61] prettyunits_1.1.1        openssl_1.4.3            viridis_0.5.1           
##  [64] haven_2.3.1              ggrepel_0.9.1            fs_1.5.0                
##  [67] magrittr_2.0.1           openxlsx_4.2.3           DO.db_2.9               
##  [70] reprex_2.0.0             reactome.db_1.74.0       hms_1.0.0               
##  [73] patchwork_1.1.1          evaluate_0.14            xtable_1.8-4            
##  [76] rio_0.5.26               readxl_1.3.1             compiler_4.0.5          
##  [79] crayon_1.4.1             shadowtext_0.0.7         htmltools_0.5.1.1       
##  [82] aplot_0.0.6              lubridate_1.7.10         DBI_1.1.1               
##  [85] tweenr_1.0.2             dbplyr_2.1.1             MASS_7.3-53.1           
##  [88] rappdirs_0.3.3           car_3.0-10               Matrix_1.3-2            
##  [91] cli_2.4.0                igraph_1.2.6             pkgconfig_2.0.3         
##  [94] rvcheck_0.1.8            GenomicAlignments_1.26.0 foreign_0.8-81          
##  [97] xml2_1.3.2               ggtree_2.4.2             svglite_2.0.0           
## [100] bslib_0.2.4              webshot_0.5.2            rvest_1.0.0             
## [103] digest_0.6.27            graph_1.68.0             rmarkdown_2.7           
## [106] cellranger_1.1.0         fastmatch_1.1-0          tidytree_0.3.4          
## [109] curl_4.3                 Rsamtools_2.6.0          graphite_1.36.0         
## [112] rjson_0.2.20             lifecycle_1.0.0          nlme_3.1-152            
## [115] jsonlite_1.7.2           carData_3.0-4            viridisLite_0.4.0       
## [118] askpass_1.1              fansi_0.4.2              pillar_1.6.0            
## [121] fastmap_1.1.0            httr_1.4.2               survival_3.2-10         
## [124] GO.db_3.12.1             glue_1.4.2               zip_2.1.1               
## [127] bit_4.0.4                ggforce_0.3.3            stringi_1.5.3           
## [130] sass_0.3.1               blob_1.2.1               memoise_2.0.0           
## [133] ape_5.5